When it appeared that her lover had returned from the dead in mid-2371, Jadzia immediately greeted Sisko with a kiss to show how glad she was that he was alive, quickly followed by a slap to the face for making her think he was dead. She didn't realize at the time that the man she thought was her lover was in fact the Benjamin Sisko from "our" universe.
In 2372, when Sisko returned to the mirror universe, Jadzia immediately pulled a knife on him, warning him to never touch her again. Jadzia later joined her new lover, Bashir, on a mission to delay the Alliance's attack on the rebel-occupied Terok Nor.
Jadzia was killed in a skirmish with the Alliance in early 2375, leaving Bashir even more irritable and unreasonable.