Houses newest patient is 18-year-old Jack, brought to the hospital after experiencing a heart attack and massive vomiting. Barely an adult himself, Jack has been the parent to his younger brother and sister since their parents died. After a brief perusal of Jacks file, House thinks hes got the diagnosis, seals it in an envelope and turns the process into a game, challenging Cameron, Foreman and Chase to figure it out on their own. When Jack is given an option that would lead to a possible reprieve from his worsening illness, hes faced with a decision that could break up his little family forever.
Meanwhile, in an attempt to extract a confession, Tritter makes it almost impossible for Wilson to practice medicine, driving a friendship-ruining wedge between House and Wilson.
original airdate--November 21,2006 rating--15.20 million
songs--Theme song--"Teardrop" by Massive Attack
Final Diagnosis--Chronic granulomatous disease
Trivia: Consistent with House's parallels with Sherlock Holmes, when he challenges his team to solve the puzzle of the diagnosis, he writes it on a piece of paper, puts it in an envelope and on the envelope writes "The game is a itchy foot." This is a play on words of Holmes' popular phrase, "The game is afoot."